Endothelial dysfunction and diabetes.

Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta

Objective: Diabetes is an important risk factor for cardiovascular events. The great percent of morbidity in patients with diabetes is due to endothelial dysfunction. The present study investigated the effects of hydroalcholic extract of Nigella sativa (N. sativa)  on contractile and dilatation response of isolated aorta in streptozotocin (STZ)-induced diabetic rat. Materials and Methods: Rats ...

THE EFFECTS OF COMBINED EXERCISE WITH AND WITHOUT DIET ON PLASMA INFLAMMATORY BIOMARKERS AND ENDOTHELIAL DYSFUNCTION IN ELDERLY PATIENTS WITH TYPE 2 DIABETES

Background: Inflammation plays an important role in the incidence and development of metabolic disorders and exercises along with dietary restrictions for weight loss. It has beneficial effects on reducing inflammatory markers, especially in type 2 diabetes. The purpose of this study was to evaluate the effect of combined exercise (resistance-aerobic) with and without diet restriction on weight...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

ارزیابی فعالیت آنزیم نیتریک اکسید سنتتاز در سلول‌های آندوتلیال آئورت موش‌های صحرایی سالم و دیابتی به روش هیستوشیمیایی NADPH دیافورزیز

Impaired endothelium-dependent relaxation of blood vessels is a common feature in diabetes but the exact underlying mechanisms have not yet been clarified. In the present study, endothelium-dependent vasorelaxation of aortic rings were evaluated in vitro in streptozocin-induced diabetic and age-matched control rats. Moreover, NO synthase activity of aortic endothelial cells was asse...

Vascular complications in diabetes mellitus: the role of endothelial dysfunction.

The endothelium is a complex organ with a multitude of properties essential for control of vascular functions. Dysfunction of the vascular endothelium is regarded as an important factor in the pathogenesis of diabetic micro- and macro-angiopathy. Endothelial dysfunction in Type I and II diabetes complicated by micro- or macro-albuminuria is generalized in that it affects many aspects of endothe...

Uncontrolled type 1 diabetes mellitus and endothelial dysfunction in adolescents.

BACKGROUND Diabetes mellitus is associated with microvascular and macrovascular diseases, potentially manifested as endothelial dysfunction. In adults with type 2 diabetes the haptoglobin genotype 1-1 has been shown to have a protective role in inhibiting the development of complications. Although complications from type 1 diabetes are infrequent during childhood, endothelial dysfunction, which...